Question: The article Cellulose Acetate Microspheres Prepared by O/W Emulsification and Solvent Evaporation Method (K. Soppinmath, A Kulkarni, et al., Journal of Microencapsulation, 2001:811-817) describes a

The article "Cellulose Acetate Microspheres Prepared by O/W Emulsification and Solvent Evaporation Method" (K. Soppinmath, A Kulkarni, et al., Journal of Microencapsulation, 2001:811-817) describes a study of the effects of the concentrations of polyvinyl alcohol (PVAL) and dichloromethane (DCM) on the encapsulation efficiency in a process that produces microspheres containing the drug ibuprofen. There were three concentrations of PVAL (measured in units of % w/v) and three of DCM (in mL). The results presented in the following table are consistent with the means and standard deviations presented in the article.

a. Construct an ANOVA table. You may give ranges for the P-values.
b. Discuss the relationships among PVAL concentration, DCM concentration, and encapsulation efficiency.

DCM 40 1H PVAL 0.5 1.0 2.0 DCM 50 75.288 74.949 72.363 98.983 99.268 95.149 96.810 94.572 86.718 89.827 94.136 96.537 82.352 79.156 80.89 76.625 76.941 72.635 95.095 95.153 92.353 86.153 91.653 87.994 80.059 79.200 77.141

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a Source DF SS MS F P PVAL 2 12541 62704 82424 0003 DCM 2 16479 82394 10831 00... View full answer

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