The main trial for the medication in Problem is conducted and involves a total of 200 patients. Patients are enrolled and randomized to receive either the experimental medication or the placebo. The data shown in Table are data collected at the end of the study after 6 weeks on the assigned treatment.

TABLE Outcome Data by Treatment

a. Generate a 95% CI for the difference in man systolic blood pressures between groups.
b. Generate a 95% CI for the difference in proportions of patients with hypertension between groups.
c. Generate a point estimate for the RR of side effects in patients assigned to the experimental group as compared to placebo. Generate a 95% CI for the RR.
Problem
A clinical trial is planned to compare an experimental medication designed to lower blood pressure to a placebo. Before starting the trial, a pilot study is conducted involving ten participants. The objective of the study is to assess how systolic blood pressure changes over time untreated. Systolic blood pressures are measured at baseline and again 4 weeks later. Compute a 95% CI for the difference in blood pressures over 4 weeks.

Experimental (n 100) Placebo (n 100) Mean (SD) systolic blood pressure 20.2 (15.4) 131.4 (18.9) Hypertensive (96) 14 side effects (%) 6 8 Baseline: 120 145 130 160 152 143 126 121 115 135 4 WeekS: 122 142 135 158 155 140 130 120 124 130