Transepidermal water loss (TEWL) is a measure of the rate that water crosses the skin through diffusion

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Transepidermal water loss (TEWL) is a measure of the rate that water crosses the skin through diffusion and evaporation. In general, damaged skin has a higher TEWL than non-damaged skin. A report submitted to the U.S. Food and Drug Administration (Therapeutic Equivalence of Topical Products A. Bunge, B. N'Dri-Stempfer, et al., 2007) described an experiment in which the outer layer of skin on a small area of the forearm was partially removed in order to measure the concentration of a certain drug. TEWL (in g/m2 per hour was measured both before and after skin removal. The results for 10 individuals were as follows.
Transepidermal water loss (TEWL) is a measure of the rate

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