Two steps in glycolysis are catalyzed by allosteric enzymes. These are: (1) step 2, catabolized by phosphoglucoisomerase, and (2) step 9, catabolized by pyruvate kinase. Suggest what metabolic products might regulate these enzymes. How might one place these regulators in figure 8.18?

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Glucose First phosphorylation (G Glucose-8-phosphate Fructose-8-phosphate Second phosphorylation (3 Fructose-1.6-diphosphate (F-1.8-P) Split of F-15-P-subsequent reactions in duplicate 3-P (G-3-P) (DHAP) Glyceraldehyde-3 phosphate Disphosphoglyceric Substrate-level Dphosphorylation ADP ADP 3-phosphoglyceric 2-phosphoglyceric acid Phosphoenolpyruvic acid Substrate-level phosphorylation ADP ADP Pyruvic acid Goes to Goes to Krebs cycle or fermentation see figures 8.20 and 8.25) Krebs cycle or fermentation