A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate molecules

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A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate molecules bind to a protein involved in cancer. The drug molecules bind the protein in a 1:1 ratio to form a drug-protein complex. The protein concentration in aqueous solution at is 25 oC is 1.50 × 10-6 M. Drug A is introduced into the protein solution at an initial concentration of 2.00 × 10-6 M Drug B is introduced into a separate, identical protein solution at an initial concentration of 2.00 × 10-6 M. At equilibrium, the drug A-protein solution has an A-protein complex concentration of 1.00 × 10-6 M and the drug B solution has a B-protein complex concentration of 1.40 × 10-6 M Calculate the Kc value for the A-protein binding reaction and for the B-protein binding reaction. Assuming that the drug that binds more strongly will be more effective, which drug is the better choice for further research?
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Chemistry The Central Science

ISBN: 978-0321696724

12th edition

Authors: Theodore Brown, Eugene LeMay, Bruce Bursten, Catherine Murphy, Patrick Woodward

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