Question: Acetolactate synthase can also transfer the two-carbon fragment from pyruvate to Î±-ketobutyrate, forming Î±-aceto-Î±-hydroxybutyrate. This is the first step in the formation of isoleucine. Propose

Acetolactate synthase can also transfer the two-carbon fragment from pyruvate to Î±-ketobutyrate, forming Î±-aceto-Î±-hydroxybutyrate. This is the first step in the formation of isoleucine. Propose a mechanism for this reaction

OH CHI- or + CH,CH330 -acetolactate SyrhaseCH CooCo TPP a-ketobutyrate CH2CH3 -aceto-a-hydroxybutyrate

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