Question: Acetolactate synthase is another TPP-requiring enzyme. It also catalyzes the decarboxylation of pyruvate but transfers the resulting two-carbon fragment to another molecule of pyruvate, forming

Acetolactate synthase is another TPP-requiring enzyme. It also catalyzes the decarboxylation of pyruvate but transfers the resulting two-carbon fragment to another molecule of pyruvate, forming acetolactate. This is the first step in the biosynthesis of the amino acids valine and leucine. Propose a mechanism for acetolactate synthase.

-O synthase TPP pyruvate CH3 acetolactate

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