Aryl halides react too slowly to undergo substitution by the SN2 mechanism with the sodium salt of

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Aryl halides react too slowly to undergo substitution by the SN2 mechanism with the sodium salt of diethyl malonate, and so the phenyl substituent of phenobarbital cannot be introduced in the way that alkyl substituents can.

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Organic Chemistry

ISBN: 978-0072905014

4th edition

Authors: Francis A. Carey

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Question Posted: Apr 30, 2016 01:50 PM

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Aryl halides react too slowly to undergo substitution by the SN2 mechanism with the sodium salt of

Question:

CH3CH2 5-Ethyl-5-phenylbarbituric acid (phenobarbital)

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The synthesis of phenobarbital requires diethyl 2phenylmalonate as ...View the full answer

Organic Chemistry

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