Question: Assume that acetyl CoA containing a 14C isotopic label in the carboxyl carbon atom is used as starting material for the biosynthesis of mevalonate, as

Assume that acetyl CoA containing a 14C isotopic label in the carboxyl carbon atom is used as starting material for the biosynthesis of mevalonate, as shown in figure. At what positions in mevalonate would the isotopic labelappear?

, H3C OH ATP ADP ATP ADP CH20-PO CH2OH H H H

, H3C OH ATP ADP ATP ADP CH20-PO CH2OH H H H H Mevalonate 5-phosphate (R)-Mevalonate ADP, P. ATP Co2 CH H - CH20-POPO CH2 CH20-POPO- H2C H H H H Mevalonate 5-diphosphate Isopentenyl diphosphate

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