Citrate synthase, one of the enzymes in the series of enzyme-catalyzed reactions known as the Krebs cycle,

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Citrate synthase, one of the enzymes in the series of enzyme-catalyzed reactions known as the Krebs cycle, catalyzes the synthesis of citric acid from oxaloacetic acid and acetyl-CoA. If the synthesis is carried out with acetyl-CoA that has radioactive carbon in the indicated position, the isomer shown here is obtained.
Citrate synthase, one of the enzymes in the series of

a. Which stereoisomer of citric acid is synthesized, R or S?
b. Why is the other stereoisomer not obtained?
c. If the acetyl-CoA used in the synthesis does not contain 14Cwill the product of the reaction be chiral or achiral?

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Organic Chemistry

ISBN: 978-0131407480

4th edition

Authors: Paula Yurkanis Bruice

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