Cortisone is an important steroidal anti-inflammatory agent. Cortisone can be synthesized efficiently from the alkene shown here.

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Of the following three chlorinated compounds, two give reasonable yields of the alkene shown above by E2 elimination with base, but one does not. Which one does not work well, and why? What does it give during attempted E2 elimination?

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Organic Chemistry structure and function

ISBN: 978-1429204941

6th edition

Authors: K. Peter C. Vollhardt, Neil E. Schore

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Question Posted: Jul 15, 2016 06:57 AM

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Cortisone is an important steroidal anti-inflammatory agent. Cortisone can be synthesized efficiently from the alkene shown here.

Question:

HOCH,O H,C HO Alkene Cortisone CI H C н.с CI HO HO

Step by Step Answer:

The two compounds which give reasonable yields of alkene by E2 elimination w...View the full answer

Organic Chemistry structure and function

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