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Autoimmune Diseases

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Biology - Immunology

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user_hassanuml Created by 9 mon ago

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Cards in this deck(37)
Who was the first scientist to describe the concept of autoimmunity?
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What is the phenomenon described by Paul Ehrlich, where the immune system protects but does not attack the body?
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What is the term for the breakdown or failure of self-tolerance, which is always experienced?
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What is the term for a disease resulting from tissue damage due to auto-immune reactions?
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What are the two mechanisms of tolerance in the immune system?
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What two essential actions occur during central tolerance?
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Where does central tolerance occur in the body?
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What are the four key characteristics of peripheral tolerance?
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What is the process called where T cells that recognize the 'right' MHC survive?
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What is the process called where T cells that react strongly with auto-antigens are deleted?
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What is AIRE and its role in the immune system?
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What is the main goal of central tolerance in the thymus?
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What are the two actions involved in central tolerance in the bone marrow for high affinity self-antigen recognition?
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What happens to B cells during central tolerance in the bone marrow when they recognize low affinity self-antigens?
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What is the role of anatomical barriers in peripheral T cell tolerance?
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What happens in peripheral tolerance when there is an absence of Signal 2 (costimulatory signal)?
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How do Tregs contribute to peripheral tolerance?
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What are the four main mechanisms underlying innate autoimmune disease?
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How does inflammation contribute to autoimmunity in the context of infection?
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What is molecular mimicry in the context of autoimmunity and infection?
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What is the organ specificity of myasthenia gravis?
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What are the symptoms of myasthenia gravis?
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What is the pathogenesis of myasthenia gravis?
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What is the treatment approach for myasthenia gravis?
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What are the clinical presentations of systemic lupus erythematodes (SLE)?
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What is the pathogenesis of SLE?
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How does NETosis contribute to autoimmune reactions?
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How is NETosis related to SLE?
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What are the three main targets of SLE treatments?
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What is a simple treatment approach for SLE related to waste disposal?
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What role do glucocorticoids play in the treatment of SLE?
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What is the role of hydroxychloroquine/antimalarials in SLE treatment?
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What is the role of cell cycle inhibitors in SLE treatment?
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What is the role of stem cell transplant in systemic sclerosis treatment?
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What is the role of rituximab, belimumab, and anifrolumab in SLE immunotherapy?
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What is the role of CAR-T-Cells therapy in treating lupus?
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What is a limitation of current SLE treatments?
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