What does Grade 1 in cancer cell maturation indicate about the cell's differentiation and survival rate? Poorly differentiated (20-50% survival) Well-differentiated (70-90% survival) Moderately differentiated (50-70% survival) Undifferentiated (<5% survival)

Well-differentiated (70-90% survival)

What is the role of the P53 gene in normal cell function, and what happens when it is turned OFF? It stimulates cell division; when OFF, it causes cell death. It promotes cell growth; when OFF, it leads to uncontrolled proliferation. It repairs DNA mistakes; when OFF, it inhibits apoptosis. It regulates metabolism; when OFF, it causes metabolic disorders.

It repairs DNA mistakes; when OFF, it inhibits apoptosis.

What is a common characteristic of cell cycle-specific chemotherapy agents? They are dose-dependent and can be delayed to give the highest tolerable dose. They act on rapidly dividing cells and are most effective when given in divided doses. They are effective in the G0 phase and treat tumors with fewer dividing cells. They cause delayed myelosuppression with a 10-day onset.

They act on rapidly dividing cells and are most effective when given in divided doses.

What is a characteristic of cell cycle non-specific chemotherapy agents? They are not dose-dependent and should not be delayed. They act on rapidly dividing cells and are most effective when given in divided doses. They are effective in the G0 phase and treat tumors with fewer dividing cells. They cause early myelosuppression with a 7-day onset.

They are effective in the G0 phase and treat tumors with fewer dividing cells.

What is the purpose of neoadjuvant chemotherapy? To treat cancer after surgery to prevent recurrence. To replace surgery as the primary treatment. To shrink or debulk a tumor before surgery. To provide palliative care for terminal patients.

To shrink or debulk a tumor before surgery.

What is the role of adjuvant chemotherapy in cancer treatment? To treat cancer after surgery to prevent recurrence. To shrink a tumor before surgery. To replace surgery as the primary treatment. To provide palliative care for terminal patients.

To treat cancer after surgery to prevent recurrence.

What is the primary goal of Phase I in clinical trials? To determine the maximum tolerated dose (MTD). To monitor long-term effects of the drug. To compare the study drug with an established drug. To test the effectiveness on specific tumors.

To determine the maximum tolerated dose (MTD).

What is the Ommaya reservoir used for in cancer treatment? Intrathecal administration of chemotherapy. Intraventricular administration of ACT medications. Subcutaneous administration of vaccines. Intravenous administration of antibiotics.

Intraventricular administration of ACT medications.

Which medications are commonly used for intrathecal ACT administration? Cytarabine (ARA-C), Methotrexate (MTX), Hydrocortisone Paclitaxel, Carboplatin, Etoposide Doxorubicin, Cyclophosphamide, Vincristine Imatinib, Dasatinib, Nilotinib

Cytarabine (ARA-C), Methotrexate (MTX), Hydrocortisone

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Medicine - Oncology

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Cards in this deck(83)

What does Grade 1 in cancer cell maturation indicate about the cell's differentiation and survival rate?

Which gene, when turned ON, becomes an oncogene and allows uncontrolled cell proliferation?

What is the role of the P53 gene in normal cell function, and what happens when it is turned OFF?

What is a common characteristic of cell cycle-specific chemotherapy agents?

What is a characteristic of cell cycle non-specific chemotherapy agents?

What is the purpose of neoadjuvant chemotherapy?

What is the role of adjuvant chemotherapy in cancer treatment?

What is the primary goal of Phase I in clinical trials?

What is the Ommaya reservoir used for in cancer treatment?

Which medications are commonly used for intrathecal ACT administration?

What is a common side effect of antimetabolites, particularly those that are heavy metal derivatives?

What is the purpose of using ice chips before and after the infusion of Fluorouracil (5-FU)?

What is a notable side effect of Capecitabine (Xeloda) when taken orally?

What is the recommended treatment for Palmar-Plantar Erythrodysesthesia (HFS) when it reaches Grade 2-3?

What precaution should be taken before administering high doses of Cytarabine (ARA-C)?

What should be avoided when taking Methotrexate (MTX) due to its interaction?

What supplementation is required when administering Pemetrexed (Alimta) for mesothelioma?

What is a significant side effect of Fludarabine Phosphate (Fludara) related to the immune system?

What is a notable pharmacokinetic change when Gemcitabine (Gemsar) is infused over 4-6 hours?

What is a specific indication for the use of Azacitadine (Onureg/Vidaza) in cancer treatment?

What is a common side effect of Decitabine (Dacogen) and Cedazuridine (Inqovi)?

What dietary restriction is necessary when taking Procarbazine (Mutalane)?

What syndrome is associated with the use of Arsenic in treating Acute Promyelocytic Leukemia (APL)?

What is the treatment for Retinoic Acid Syndrome caused by Tretinoin/All-trans-retinoic acid (ATRA)?

What is a dose-limiting side effect of plant alkaloids?

What is a critical administration guideline for Vincristine (Oncovin)?

What is a notable side effect of high-dose Etoposide (VP-16) administration?

What is a contraindication for administering Taxanes (MI)?

What is a necessary precaution when administering Paclitaxel (Taxol)?

What is a common side effect of Docetaxel (Taxetere) that requires premedication?

What is a unique characteristic of Paclitaxel Protein/Albumin-Bound (Abraxane) administration?

What is a dose-limiting side effect of Irinotecan (CPT-11/CAMPTOSAR)?

What is the recommended treatment for early diarrhea caused by Irinotecan?

What is the treatment protocol for late diarrhea caused by Irinotecan?

What is the role of Leucovorin when used with Methotrexate?

What is a delayed side effect of Ifosfamide (Ifex) that requires monitoring?

What is a delayed side effect of high-dose Cyclophosphamide (Cytoxan)?

What is a common long-term side effect of alkylating agents?

What is a unique side effect of Oxaliplatin (Eloxatin) related to temperature?

What is a necessary precaution when administering Cisplatin (Platinol)?

What is a notable side effect of Doxorubicin (Adriamycin) related to urine?

What is a pulmonary side effect of Bleomycin that requires monitoring?

What is a common side effect of Nitrosoureas like Carmustine and Lomustine?

What is a common side effect of Carboplatin that requires monitoring?

What does the term 'nadir' refer to in the context of chemotherapy?

What is a common side effect of growth factors like Filgrastim (Neupogen)?

What is a common side effect of growth factors like Epoetin (Procrit) related to red blood cells?

What is a common side effect of growth factors like Romiplostim (Nplate) related to platelets?

What is a risk associated with Selective Estrogen Receptor Modulators (SERMs) like Tamoxifen?

What is a common side effect of Aromatase Inhibitors like Anastrozole related to musculoskeletal symptoms?

What is a common side effect of GnRH Agonists like Lupron related to bone health?

What is a common side effect of GnRH Antagonists like Firmagon related to injection sites?

What is the mechanism of action of Zytiga in prostate cancer treatment?

What is the purpose of CTCAE grading levels in cancer treatment?

Who should be contacted for assistance with financial and quality of life issues in cancer survivorship?

What is a common side effect of NK-1 Antagonists like Emend?

What are common side effects of 5-HT3 Inhibitors like Aloxi and Zofran?

What are common long-term endocrine toxicities associated with cancer treatment?

What is a recommended management strategy for ocular side effects in cancer treatment?

What is a common symptom of Hand-Foot Skin Reaction (HFSR) in cancer treatment?

What is a common symptom of Hand-Foot Syndrome (HFS) in cancer treatment?

What is a common management strategy for cutaneous toxicities in cancer treatment?

What are the '3 Ms' associated with mucositis in cancer treatment?

What is a common side effect of Melphalan that requires premedication with ice chips?

What is a common acute side effect of Myleran (Busulfan) that requires monitoring?

What is a common interaction concern with TKIs/MKIs (-Nibs) in cancer treatment?

What pathway do many targeted therapies interfere with in cancer treatment?

What is a common side effect of PARP Inhibitors used in ovarian cancer treatment?

What is a consideration for using Bevacizumab (Avastin) in cancer treatment?

What is a common side effect of Proteosome inhibitors like Bortezomib in myeloma treatment?

What is the mechanism of action of monoclonal antibodies (MAOIs) in cancer treatment?

What is a common treatment for 'itis' side effects in immunotherapy?

What is a significant risk associated with Immunomodulators like Thalidomide?

What pathways do checkpoint inhibitors target in cancer treatment?

What is a common concern with Nivolumab (Opdivo) related to liver function?

What is a pulmonary concern with Keytruda (Pembrolizumab) in cancer treatment?

What are other checkpoint inhibitors besides Nivolumab and Pembrolizumab?

What pathway does Ipilimumab (Yervoy) target in cancer treatment?

What is a common effect of CAR-T therapy related to B cells?

What is a common neurotoxicity associated with Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS)?

What is a common treatment for Cytokine Release Syndrome (CRS) in cancer therapy?

What is a common dermatologic toxicity associated with Epidermal Growth Factor Receptor inhibitors?

What is a common vascular side effect of Vascular Endothelial Growth Factor inhibitors?

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