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Histidine is an amino acid with three titratable groups: an - NH3+ group (pKa = 9.2), a -COOH group 1

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Histidine is an amino acid with three titratable groups: an - NH3+ group (pKa = 9.2), a -COOH group 1 (pKa = 1.8), and an imidazole (amine-like) group 1 (pKa = 6.0). Te titration curve for histidine is shown below with four points highlighted.
a. Identify which point on the titration curve corresponds to the pKa for each of the titratable groups, and which point corresponds to the pI. Explain your choices.
b. Calculate the value of pI for histidine.

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a Moles OH added per mole histidine b See Figure 5 7 wh…View the full answer


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Biochemistry Concepts and Connections

Biochemistry Concepts and Connections

ISBN: 978-0321839923

1st edition

Authors: Dean R. Appling, Spencer J. Anthony Cahill, Christopher K. Mathews

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Question Posted: April 21, 2016 04:10:18
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