Hydrophobic residues usually appear at the first and fourth positions in the seven-residue repeats of polypeptides that

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Hydrophobic residues usually appear at the first and fourth positions in the seven-residue repeats of polypeptides that form coiled coils.
(a) Why do polar or charged residues usually appear in the remaining five positions?
(b) Why is the sequence Ile-Gln-Glu-Val-Glu-Arg-Asp more likely than the sequence Trp-Gln-Glu-Tyr-Glu-Arg-Asp to appear in a coiled coil?
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Fundamentals of biochemistry Life at the Molecular Level

ISBN: 978-0470547847

4th edition

Authors: Donald Voet, Judith G. Voet, Charlotte W. Pratt

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