If a protonated His residue acts as the proton donor in an acid-catalyzed enzymatic reaction, what happens

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If a protonated His residue acts as the proton donor in an acid-catalyzed enzymatic reaction, what happens to the enzyme's activity as the pH increases to a value that exceeds the pKR of that residue?
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Fundamentals of biochemistry Life at the Molecular Level

ISBN: 978-0470547847

4th edition

Authors: Donald Voet, Judith G. Voet, Charlotte W. Pratt

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