Question: In addition to the pathway described in Figure 16.31, eukaryotes can also synthesize phosphatidylcholine and phosphatidylethanolamine, starting with free choline or ethanolamine, respectively. In this

In addition to the pathway described in Figure 16.31, eukaryotes can also synthesize phosphatidylcholine and phosphatidylethanolamine, starting with free choline or ethanolamine, respectively. In this salvage pathway, the phosphodiester linkage in the glycerophospholipid is formed by activating the -OH of the head group instead of the diacylglycerol moiety. Propose a pathway for the synthesis of phosphatidylcholine from free choline using this salvage route.

NH Phosphatidic acid CDP-diacylglycerol synthase OH OH NH CDP diacylglycerol Pyrophosphatase 2 P, OH OH CTP

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