In an experiment conducted at the National Institute of Environmental Health Sciences, the absorption (or uptake) of

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In an experiment conducted at the National Institute of Environmental Health Sciences, the absorption (or uptake) of a chemical by a rat on one of two different diets, I or II, was known to be affected by the weight (or size) of the rat. A completely randomized design utilizing four rats on each diet was employed in the experiment, and the initial weight of each rat was recorded so that the diets could be compared after the researchers adjusted for the effect of initial weight. The data for the experiment are given in the following table.
In an experiment conducted at the National Institute of Environmental

a. Using the initial weight as a covariate, state the ANACOVA regression model for comparing the two diets (set Z = -1 if diet I is used and Z = 1 if diet II is used).
b. Use the computer results given next to determine the adjusted mean responses for each diet, controlling for initial weight.
c. Use the ANACOVA regression model defined in part (a) to test whether the two diets differ significantly.
d. Test whether the two diets differ significantly, completely ignoring the covariate. How do the two testing procedures compare?
e. Determine a 95% confidence interval for the true difference in the adjusted mean responses.

In an experiment conducted at the National Institute of Environmental
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Applied Regression Analysis and Other Multivariable Methods

ISBN: 978-1285051086

5th edition

Authors: David G. Kleinbaum, Lawrence L. Kupper, Azhar Nizam, Eli S. Rosenberg

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