Individuals with systemic lupus erythematosus (SLE) produce antibodies to DNA and phospholipids. (a) Explain why normal individuals
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(a) Explain why normal individuals do not make antibodies to these substances.
(b) During a normal response to a viral or bacterial infection, the immune system produces large amounts of antigen-specific antibodies, and the resulting antigen-antibody complexes are subsequently removed from the circulation and degraded.
Explain why antigen-antibody complexes accumulate in the tissues of individuals with SLE.
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a Normally DNA is intracellular and not accessible to B cells so no antiDNA antibodies ar...View the full answer
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Related Book For 
Fundamentals of biochemistry Life at the Molecular Level
ISBN: 978-0470547847
4th edition
Authors: Donald Voet, Judith G. Voet, Charlotte W. Pratt
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