Leuprolide is a synthetic nonapeptide used to treat both endometriosis in women and prostate cancer in men.

Question:

(a) Both C-terminal and N-terminal amino acids in Leuprolide have been structurally modified. Identify the modifications.

(b) One of the nine amino acids in Leuprolide has D stereochemistry rather than the usual L. Which one?

(d) What charge would you expect Leuprolide to have at neutralpH?

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Organic Chemistry

ISBN: 9780495112587

7 Edition

Authors: John McMurry

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Question Posted: Mar 08, 2011 05:48 AM

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Leuprolide is a synthetic nonapeptide used to treat both endometriosis in women and prostate cancer in men.

Question:

но H-N N-, NHCH2CH3 N. N. H. OH H-N N-H HN= Leuprolide NH2

Step by Step Answer:

Glu E NH His H N NH NH Leuprolide Trp Ser W TyrLeu L OH HN L NH NH NH CH3 LeuArgProNHE ...View the full answer

Organic Chemistry

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