Question: Quinolines are commonly synthesized by a method known as the Skraup synthesis, which involves the reaction of aniline with glycerol under acidic conditions. Nitrobenzene is
Quinolines are commonly synthesized by a method known as the Skraup synthesis, which involves the reaction of aniline with glycerol under acidic conditions. Nitrobenzene is added to the reaction mixture to serve as an oxidizing agent. The first step in the synthesis is the dehydration of glycerol to propenal.
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a. What product would be obtained if para-ethylaniline were used instead of aniline?
b. What product would be obtained if 3-hexen-2-one were used instead of glycerol?
c. What starting materials are needed for the synthesis of 2,7-diethyl-3-methylquinoline?
H2so CHCH CH OH OH OH glycerol
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