Some anaerobic bacteria use an alternative pathway for glucose catabolism, shown below, that converts glucose to acetate rather than to pyruvate. The first part of this pathway (glucose to fructose-1, 6-bisphosphate) is identical to the glycolytic pathway. In the second part of the alternative pathway, Enzymes 1-6 all have mechanisms/activities analogous to enzymes in glycolysis. Note that there are two
Some anaerobic bacteria use an alternative pathway for glucose catabolism, shown below, that converts glucose to acetate rather than to pyruvate. The first part of this pathway (glucose to fructose-1, 6-bisphosphate) is identical to the glycolytic pathway. In the second part of the alternative pathway, Enzymes 1-6 all have mechanisms/activities analogous to enzymes in glycolysis. Note that there are two C-C bond cleavage reactions in this new pathway: A→B + C (Enzyme 1) and C→B + D. All the steps where ATP is consumed or generated have been shown; however, the addition or loss of NAD+ /NADH, Pi, H2O, or H+ has not been shown explicitly. Draw the structures for the intermediates B, F, G, H, and I, and include other reaction participants as needed.
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Related Book For
Biochemistry Concepts and Connections
1st edition
Authors: Dean R. Appling, Spencer J. Anthony Cahill, Christopher K. Mathews
ISBN: 978-0321839923