Some bacteria catabolize glucose by the Entner-Doudoroff pathway, a variant of glycolysis in which glucose-6-phosphate is converted to 6-phosphogluconate (as in the pentose phosphate pathway) and then to 2-keto-3-deoxy-6-phosphogluconate (KDPG).

Next, an aldolase acts on KDPG.
(a) Draw the structures of the products of the KDPG aldolase reaction.
(b) Describe how these reaction products are further metabolized by glycolytic enzymes. (c) What is the ATP yield when glucose is metabolized to pyruvate by the Entner Doudoroff pathway? How does this compare to the ATP yield of glycolysis?

Transcribed Image Text:

coo H-C-H H-C-OH CH2OPO KDPG