Question: Specific DNA-binding proteins mainly contact DNA through hydrogen bonds in the major groove of B-DNA. (a) Why might sequence-specific binding be more common in the

Specific DNA-binding proteins mainly contact DNA through hydrogen bonds in the major groove of B-DNA.
(a) Why might sequence-specific binding be more common in the major groove than in the minor groove?
(b) What hydrogen-bond contacts can proteins make with the bases in the major groove?
Are these different from those in the minor groove?

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