Question: Below are shown two views of the backbone representation of the Myc-Max complex binding to DNA (PDB ID: 1npk). Side view of Myc-Max bound to
Below are shown two views of the backbone representation of the Myc-Max complex binding to DNA (PDB ID: 1npk).
-1.png)
Side view of Myc-Max bound to DNA
-2.png)
Top view of Myc-Max bound to DNA(looking down the DNA helical axis)
Myc and Max are members of the basic helix-loop-helix (bHLH) class of DNA-binding proteins. Myc (red) and Max (blue) associate via a coiled-coil interaction and bind DNA as a dimer.
a. Are the helices bound to the DNA likely to be amphiphilic? Explain.
b. Where do you predict the N- and C-termini are located for Max?
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a No DNA is charged and therefore polar so most of the DNAbinding ... View full answer
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