In most people, the first six amino acids in their -globin polypeptide chains are: The DNA triplet

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In most people, the first six amino acids in their β-globin polypeptide chains are:


The DNA triplet coding for the sixth amino acid (Glu) in most people is CTT. In some people this DNA triplet is CAT.

a. What type of mutation is the change from CTT to CAT?

b. Use Appendix 2 to identify the amino acid in the β-globin polypeptide chains of people with this mutation.

c. State the consequences for a person of having two copies of the mutated gene.

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Cambridge International AS And A Level Biology

ISBN: 9781107636828

4th Edition

Authors: Mary Jones, Richard Fosbery, Jennifer Gregory, Dennis Taylor

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