It is proposed to sterilize the growth medium fed to a continuous bioreactor either by holding it

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It is proposed to sterilize the growth medium fed to a continuous bioreactor either by holding it at 120 °C for 15 minutes or at 140 °C for 3 minutes. The feed must contain 12 mg/l of vitamin C and 0.3 mg/l of thiamin. Leskova et al. (2006) give the following first-order rate constants for thermal decomposition of these vitamins:


Vitamin Ascorbic acid (vitamin C) Thiamin (vitamin B1) ko (S-) 3.6  10 1.88 x 10 Ea (kJ/mol) 46 97 Where the


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Chemical Engineering Design

ISBN: 9780081025994

6th Edition

Authors: Ray Sinnott, R.K. Sinnott, Sinnott Gavin Towler

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