The NS1 protein in the H3N2 strain of the influenza virus has a C-terminal sequence of KMARTARSKV

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The NS1 protein in the H3N2 strain of the influenza virus has a C-terminal sequence of –KMARTARSKV (using one-letter amino acid abbreviations). The N-terminus of histone H3 has the sequence ARTKQTARKS–.
(a) Identify the four-residue segment that is almost identical in the two proteins.

(b) NS1 does not appear to compete with histone H3 for DNA binding (since the N-terminus of H3 does not directly contact the DNA). How else might NS1’s similarity to H3 interfere with host gene expression?

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Fundamentals Of Biochemistry Life At The Molecular Level

ISBN: 9781118918401

5th Edition

Authors: Donald Voet, Judith G Voet, Charlotte W Pratt

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