1. Is there a significant difference in bioavailability of the four different preparations? Use ANOVA methods to assess this based on the 6-week data in comparison with baseline?

2. Use the methods in Problem 12.21 to compare the bioavailability of the four preparations at 8 weeks vs. baseline?

3. Use the methods in Problem 12.21 to compare the bioavailability of the four preparations at 10 weeks vs. baseline?

4. Use the methods in Problem 12.21 to compare the bioavailability of the four preparations at 12 weeks vs. baseline?

5. Use the methods in Problem 12.21 to compare the bioavailability of the four preparations based on the average plasma beta-carotene at (6, 8, 10, and 12 weeks) vs. baseline?

Table 12.35: Format of BETACAR.DAT

 

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Code Variable Column Preparation Subject number First baseline level Second baseline level 1 = SOL; 2= ROCHE; 3 = BASF-30; 4 = BASF-60 3-4 6-8 10-12 Week 6 level Week 8 level Week 10 level Week 12 level 14-16 18-20 22-24 26-28