Assess whether there are any significant treatment or carry-over effects of SBP or DBP in study 1?

Three separate two-period cross-over studies were performed, based on different groups of subjects. Study 1 compared 0.625 mg estrogen with placebo. Study 2 compared 1.25 mg estrogen with placebo. Study 3 compared 1.25 mg estrogen with 0.625 mg estrogen. Subjects received treatment for 4 weeks in each active-treatment period; a 2-week washout period separated the two active-treatment periods.