Evaluate whether age is an effect modifier of the relationship between aspirin and CVD?

Cardiovascular Disease

The Women€™s Health Study randomly assigned 39,876 initially healthy women ages 45 years or older to receive either 100 mg of aspirin on alternate days or placebo and monitored them for 10 years for a major cardiovascular event [52]. Table 13.60 shows the results stratified by age at randomization.

Table 13.60 Incidence of CVD by treatment group and age in the Women€™s Health Study

 

Use logistic regression methods to characterize the relationship between aspirin assignment and the odds of CVD, by doing the following.

Treatment group CVD=yos Age CVD=no Aspirin Placebo Aspirin 45-54 163 11,847 161 11,854 55-64 183 5693 Placebo 186 5692 Aspirin 265 131 1917 Placebo 175 1874