Is there a significant difference between the fracture rate in individual treated women and the fracture rate in the untreated women? (Report a two-tailed p-value.)

Endocrinology

Osteoporosis is an important cause of morbidity in middle-aged and elderly women. Several drugs are currently used to prevent fractures in postmenopausal women.

Suppose the incidence rate of fractures over a 4-year period is known to be 5% among untreated postmenopausal women with no previous fractures.

A pilot study conducted among 100 women without previous fractures aims to determine whether a new drug can prevent fractures. It is found that two of the women have developed fractures over a 4-year period.