Perform the test in Problem 8.56 and report a two tailed p-value?

Cardiovascular Disease

Lipolysis is a regulator of energy metabolism. Genes encoding proteins that regulate energy metabolism through lipolysis are likely to play an important role in determining susceptibility to metabolic disorders. A study was performed sequencing 12 lipolytepathway genes in an Amish population (Albert et al. [11]). A 19 base pair (bp) deletion was identified in one of the genes that was present in approximately 5% of the Amish population and 0.2% of the non-Amish population of European descent. The deletion was genotyped in 2738 Amish persons, of whom 140 were heterozygous for the deletion (i.e., the ID genotype), 1 was homozygous (i.e., the DD genotype), and 2597 persons did not have the deletion (i.e., the II genotype). In Table 8.19, we compare the mean HDL cholesterol between subjects with the ID vs. II genotypes.

Table 8.19: Mean HDL cholesterol according to LIPE deletion genotype

 

+ mg/dl

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LIPE deletion Mean t sd* genotype II 55.2 2597 15.0 49.0 13.3 140 ID