Should a one-sided or a two-sided test be performed? Why?

Infectious Disease

The degree of clinical agreement among physicians on the presence or absence of generalized lymphadenopathy was assessed in 32 randomly selected participants from a prospective study of male sexual contacts of men with acquired immunodeficiency syndrome (AIDS) or an AIDS-related condition (ARC) [8]. The total number of palpable lymph nodes was assessed by each of three physicians. Results from two of the three physicians are presented in Table 8.15.

Table 8.15: Reproducibility of assessment of number of palpable lymph nodes among sexual contacts of AIDS or ARC patients

 

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Number of palpable lymph nodes Patient Doctor A Doctor B Difference 1 4 3 17 8. 3 4 11 13 -2 5 12 -1 3 10 11 12 13 4 14 4 4 15 16 17 4 18 12 19 10 20 11 -2 21 5 22 3 23 12 12 24 25 13 4 26 12 27 6. -3 28 19 10 29 8. 30 15 6. 31 6. 32 5 4 Mean 7.91 5.16 2.75 sd 3.93 4.35 2.83 32 32 32