Suppose the new drug is hypothesized to yield a fracture rate of 2.5% over a 4-year period.
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Suppose the new drug is hypothesized to yield a fracture rate of 2.5% over a 4-year period. How many subjects need to be studied to have an 80% chance of detecting a significant difference between the incidence rate of fractures in treated women and the incidence rate of fractures in untreated women (assumed to be 5% from Problem 7.105)?
Suppose that 8 of the previous 100 women have developed abdominal pain during the trial, while only 1.5% would be expected to develop abdominal pain based on previous natural history studies.
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