Question: What will be the revised sample size estimate in Problem 10.44 if the lack of compliance is taken into account? Investigators expect that not all

What will be the revised sample size estimate in Problem 10.44 if the lack of compliance is taken into account?


Investigators expect that not all participants will comply. In particular, they project that 5% of the treatment group will not comply with drug therapy and that 10% of the control group will start taking cholesterol-lowering drugs outside the study.

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