Question: A crossover study analyzed by B. Jones and M. Kenward (1987, Stat. Med. 6: 555564) compared three drugs on a binary outcome (success = 1,

A crossover study analyzed by B. Jones and M. Kenward (1987, Stat. Med. 6:

555–564) compared three drugs on a binary outcome (success = 1, failure =

0). Counts for the eight possible response patterns for drugs (A, B, C) were 6 for 000, 9 for 001, 4 for 010, 45 for 011, 3 for 100, 7 for 101, 4 for 110, and 8 for 111. Compare the drugs using

(a) a GLMM,

(b) a marginal model. In each case, state all assumptions, and interpret results.

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