In 1991, chemists at the University of Iowa were able to prepare trifluoromethylcopper(I), F 3 CCu. This

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In 1991, chemists at the University of Iowa were able to prepare trifluoromethylcopper(I), F3C—Cu. This compound could be used to prepare trifluoromethyl-substituted aromatic compounds by reactions like the one shown in Fig. P18.80.

(a) Suggest a stepwise mechanism for this transformation. In 2013, chemists at Imperial College (London) showed that they could prepare F3C—Cu containing the isotope 18F. They could use this compound to prepare a number of important drugs that contain trifluoromethyl groups. Each synthesis took less than an hour.

(b) Why might this advance be medically important?HC Figure P18.80 -I + F3C-Cu trifluoromethylcopper (1) HC- CF3+ I-Cu

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Organic Chemistry

ISBN: 9781936221349

6th Edition

Authors: Marc Loudon, Jim Parise

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