Using the curved-arrow notation, write in detail the mechanisms for the reactions in (a) Eq. 27.42a (b)

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Using the curved-arrow notation, write in detail the mechanisms for the reactions in
(a) Eq. 27.42a O Ph N C S + HN-CH-C-NH- Pep phenyl isothiocyanate (Edman reagent) R MeNPh pyridine/HO PhNHCNH N CH R a

(b) Eq. 27.42b PhNHC -NH- Pep CH-R a thiourea CF3COH x CH-R PhNHC a thiazolinone + HN- Pep a new peptide, one residue

(c) Eq. 27.42cPhNH-C O= CH-R thiazolinone HO, H3O+ HO PhNH CH-R NH S a thiourea PhN C- side chain of the amino-terminal

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Related Book For  answer-question

Organic Chemistry

ISBN: 9781936221349

6th Edition

Authors: Marc Loudon, Jim Parise

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