5. Consider the problem discussed by Anik and Sukumar (1981). They studied the solubility of a butoconazole nitrate imidazole antifungal agent in a mixture of x1: polyethylene glycol 400, x2: glycerin, x3: polysorbate 60, x4:

water, and x5: poloxamer 407. Constraints on the mixture components are shown below.

(a) Use the %adx macros to nd the extreme vertices of the experimental region, and verify that the ones listed in Table 11.10 are correct.

(b) Given the data from Anik and Sukumar (1981) experiments shown in Table 11.10, t the Schee quadratic model to the four mixture compo-
nents that are not constant.

0.10 0.40 0.102 0.40 0.003 0.08 0.304