The bioconversion of glucose to ethanol is carried out in a packed-bed, immobilized cell bioreactor containing yeast
Question:
The bioconversion of glucose to ethanol is carried out in a packed-bed, immobilized cell bioreactor containing yeast cells entrapped in Ca?alginate beads. The rate-Iimiting substrate is glucose, and its concentration in the feed bulk liquid phase is S 0i ,- = 5 g/l. The nutrient flow rate is F = 2 I/min. The particle size of Ca-alginate beads is D p = 0.5 cm. The surface area of the alginate beads per unit volume of the reactor is a = 25 cm 2 /cm 3 , and the cross?sectional area of the bed is A = 100 cm 2 .
Following are the rate constants for this conversion:
The following rate expression:
Assuming a first-order reaction-kinetics (e.g., relatively low substrate concentrations), determine the required bed height for 80% conversion of glucose to ethanol at the exit stream.
Where
And
Applied Regression Analysis and Other Multivariable Methods
ISBN: 978-1285051086
5th edition
Authors: David G. Kleinbaum, Lawrence L. Kupper, Azhar Nizam, Eli S. Rosenberg