Question: 1. Consider the synthetic sequence below, and answer the following questions. a) Estimate the pKa values of the enolizable positions in the ketone at left

1. Consider the synthetic sequence below, and answer the following questions.

1. Consider the synthetic sequence below, and answer the following questions. a) Estimate the pKa values of the enolizable positions in the ketone at left (grey circles) b) Do you think it would be possible to form the non-conjugated enolate from this ketone under any conditions? (yes or no) c) Provide a method (reagents, solvent, equivalents, etc.) for each step in the sequence Meo Meo HH -H Meo Meo Meo OME OME relative configuration is irrelevant adapted from: J. Am. Chem. Soc. 2002, 124, 12416 Meo

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