1) Describe how wild-type BRCA2 is thought to be involved in controlling the repair of DNA double-stranded...
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1) Describe how wild-type BRCA2 is thought to be involved in controlling the repair of DNA double-stranded breaks (DSB) by homologous recombination in mammalian cells?
2) Can you propose a possible therapeutic strategy(ies) that might correct any homologous recombination deficiencies in cells expressing BRCA26174delt protein?|
3) Explain the concept of “synthetic lethality”. How might you use this strategy to eliminate cells expressing BRCA26174delt protein.
Related Book For
Elementary Principles of Chemical Processes
ISBN: 978-0471720638
3rd Edition
Authors: Richard M. Felder, Ronald W. Rousseau
Posted Date: