Question: 1- Modify (add to) the structure below to make a long-acting PGE 2 . Add all functional groups needed. Correctly name this molecule. 2-Describe in

1- Modify (add to) the structure below to make a long-acting PGE2. Add all functional groups needed. Correctly name this molecule.

1- Modify (add to) the structure below to make a long-acting PGE2.

2-Describe in words how aspirin acts as suicide inhibitor of COX. Include the chemical interactions and any modifications to COX.

3. Describe in words the strategy used to make COX2-specific NSAIDs. Include chemical details and comparison if COX1 and COX2.

4. Describe the typical SAR for most nonselective NSAIDs.

5. Describe the cause of the primary and secondary insults induced by most NSAIDs.

COOH

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