$1)$ The sentence $$Although a press release issued with the study prominently mentioned the link between silicon and bone health, the study itself did not look at bone mineral density or analyze any patient data $.$is equivalent to:

A$-$ Despite that a press release issued with the study prominently mentioned the link between silicon and bone health, the study itself did not look at bone mineral density or analyze any patient data.

B$-$ Despite a press release issued with the study prominently mentioned the link between silicon and bone health, the study itself did not look at bone mineral density or analyze any patient data.

C$-$ Despite the fact that a press release issued with the study prominently mentioned the link between silicon and bone health, the study itself did not look at bone mineral density any patient data.

D$-$ Inspite of a press release issued with the study prominently mentioned the link between silicon and bone health, the study itself did not look at bone mineral density or analyze any patient data.

E$-$ In spite a press release issued with the study prominently mentioned the link between silicon and bone health, the study itself did not look at bone mineral density or analyze any patient data.