1. What is the mutation that causes 70% of cases of Cystic Fibrosis? Does it cause...

 

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1. What is the mutation that causes 70% of cases of Cystic Fibrosis? Does it cause a frameshift? What is the inheritance pattern of the disease? What population has a high number of heterozygotes? 4 pts ANSWER:_ 2. What technique did the CF researcher invent that saved them a lot of time building contigs from their genomic libraries? Name the technique they started with and the improvement. 2 pts ANSWER: 3. What is the significance of CpG islands in genomic DNA? 2 pts ANSWER:_ 4. Why did the researchers probe a cDNA library from sweat glands? What other tissue would produce a positive result? Can you name a tissue that would not produce a hit? 3 pts ANSWER: 5. The CF researchers found that the protein sequence was homologous to other ion channels in the database, using a program like BLAST. What website would you go to if you want to find similar sequences to your favorite gene? (hint: you had this in a previous lecture, don't invent a different one) 1 pt ANSWER:_ 1. What is the mutation that causes 70% of cases of Cystic Fibrosis? Does it cause a frameshift? What is the inheritance pattern of the disease? What population has a high number of heterozygotes? 4 pts ANSWER:_ 2. What technique did the CF researcher invent that saved them a lot of time building contigs from their genomic libraries? Name the technique they started with and the improvement. 2 pts ANSWER: 3. What is the significance of CpG islands in genomic DNA? 2 pts ANSWER:_ 4. Why did the researchers probe a cDNA library from sweat glands? What other tissue would produce a positive result? Can you name a tissue that would not produce a hit? 3 pts ANSWER: 5. The CF researchers found that the protein sequence was homologous to other ion channels in the database, using a program like BLAST. What website would you go to if you want to find similar sequences to your favorite gene? (hint: you had this in a previous lecture, don't invent a different one) 1 pt ANSWER:_