$+2100$ pts

Sign in

$/3000$

Due: Fri, Dec $6$

Question $24$ of $30$

The introduction of the small RNAs will produce a protein that is somewhat shortened because an exon is skipped and some amino acids are missing, but it may still result in a protein that has some function. The small RNAs, antisense RNAs, used for exon skipping are complementary to bases in the pre$-$mRNA, which will prevent proper associating of spliceosome for intron removal. $($A$.$ Goyenvalle et al$.,2004.$ Science $306$:$1796-1799).$

In order to skip the mutated exon and potentially treat DMD$,$ select the best antisense RNA targets.

a $3\text{'}$ splice site of the intron upstream of the exon to be skipped

a branch point of the intron upstream of the exon to be skipped

a $5\text{'}$ splice site of the intron upstream of the exon to be skipped

a $3\text{'}$ splice site of the intron downstream of the exon to be skipped

Question Source: Pierce $6$e$-$Genetics: A Conceptual Approach $|$ Publisher. W$.$H$.$ Freem$$n