Question: ( 2 5 points ) Polycyclic, polyether marine natural products ( secondary metabolites ) display a wide range of biological activities. The structure of a

(25 points) Polycyclic, polyether marine natural products (secondary metabolites) display a wide range of biological activities. The structure of a natural product from this class, Brevetoxin B, is shown below.
In an attempt to develop a synthetic methodology that would enable the syntheses of such ladder polyether natural products, Jamison and co-workers from Massachusetts Institute of Technology discovered a new cascade reaction (shown below) and disclosed their findings in Science magazine in 2007(Science 2007,317,1189). Propose a plausible mechanism for this transformation. Please use curved arrows in your mechanism.
 (25 points) Polycyclic, polyether marine natural products (secondary metabolites) display a

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