Question: ( 2 5 points ) Polycyclic, polyether marine natural products ( secondary metabolites ) display a wide range of biological activities. The structure of a
points Polycyclic, polyether marine natural products secondary metabolites display a wide range of biological activities. The structure of a natural product from this class, Brevetoxin B is shown below.
In an attempt to develop a synthetic methodology that would enable the syntheses of such ladder polyether natural products, Jamison and coworkers from Massachusetts Institute of Technology discovered a new cascade reaction shown below and disclosed their findings in Science magazine in Science Propose a plausible mechanism for this transformation. Please use curved arrows in your mechanism.
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