2. Buffers. Physiological pH inside of living cells is about 7.4. The total free concentration of...
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2. Buffers. Physiological pH inside of living cells is about 7.4. The total free concentration of phosphate inside of cells is about 1 mM. Phosphate exists in four different protonation states (see the figure below, taken from your textbook). H₂PO4 H₂PO HPO ²- PO,³- pk = 2.12 pk = 7.21 pk- =12.67 Unnumbered 1p16 my ev Freeman and Company A) Which form of phosphate is the most abundant at physiological pH? B) Suppose that 100 ml of cellular extract is treated with 50 ml of 0.5 mM HCI. What is the final pH? [Assume that the HCl reacts only with the phosphate buffer in the cell extract.] Which form of phosphate is most abundant now? 2. Buffers. Physiological pH inside of living cells is about 7.4. The total free concentration of phosphate inside of cells is about 1 mM. Phosphate exists in four different protonation states (see the figure below, taken from your textbook). H₂PO4 H₂PO HPO ²- PO,³- pk = 2.12 pk = 7.21 pk- =12.67 Unnumbered 1p16 my ev Freeman and Company A) Which form of phosphate is the most abundant at physiological pH? B) Suppose that 100 ml of cellular extract is treated with 50 ml of 0.5 mM HCI. What is the final pH? [Assume that the HCl reacts only with the phosphate buffer in the cell extract.] Which form of phosphate is most abundant now?
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