21. QuestionPlease provide an explanation for the terms negative and positive (direct and indirect) Coombs' haemolytic anemia.2.What are the Coombs' test's guiding principles? Aldomet (alpha methyldopa) is frequently linked to autoimmune hepatitis or haemolytic anemia.Is it safe to donate blood to a normal person who has previously been treated with this drug and has a positive Coombs test? Question 23: In sickle-cell anemia, what causes priapism? Question 24: Are any of the glomerular disorders connected to sickle cell disease? What exactly is the acute chest syndrome, question 25? Question 26: Recurrent leg ulcers and infections are common in thalassaemia intermedia patients.What is this thing's mechanism? Question 27: What is the process by which carbonyl iron and iron polymaltose complex absorb iron? Question 28: Serum ferritin and hepatic iron stores should be measured to determine if a patient has iron overload in thalassaemia major.How are the iron stores in the liver measured?Using a liver biopsy?And isn't it sufficient to measure serum ferritin? Question 29: Are the sucrose haemolysis test and the Ham's acid serum test typically used in the investigation for paroxysmal nocturnal hemoglobinuria (PNH)?What are these tests' guiding principles? After multiple phlebotomies, why isn't the blood of polycythaemia vera patients used for transfusions?Because the red blood cells do not contain a nucleus, even though this is a premalignant condition, a transfusion of only pure red blood cells (RBCs) would be extremely beneficial